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Hypoglycemia is one of the most common causes of death in the transitioning of a small breed puppy.  The following information will help you see the signs and symptoms of this illness and help you determine steps to take to keep your puppy healthy and avoid problems.
PREVENTION is the KEY in most cases when trying to avoid a hypoglycemic episode in a small puppy!   You must be sure that the puppy is eating properly, 4-5 small meals a day...usually a mix of premium dry and canned...And allow a free choice of premium dry food.   In addition, puppy must be kept in a warm environment, free of chilled/cool air...and you must not allow your puppy to over exert itself...Usually no more than 20 minutes of hard/running play time.  Puppies usually have two speeds...full blast or ‘crash'.  Allow your puppy to sleep and rest, this is extremely important.  Keep on hand Nutrical and/or Karo Syrup for emergencies....AND always, in an emergency situation, SEEK VETERINARY CARE IMMEDIATELY!
Hypoglycemia or low blood sugar is a possible problem with all toy breed puppies. Veterinarians unfamiliar with toys often misdiagnose the condition as viral hepatitis or encephalitis. As a toy breeder or pet owner, it is important to recognize the symptoms of hypoglycemia and know how to treat it. Hypoglycemia is easily treatable in the early stages, but fatal if allowed to progress. Many puppies are lost needlessly to hypoglycemia because of ignorance on the part of their owner or veterinarian.
The first sign of hypoglycemia is the puppy slowing down and then acting listless. The puppy will then begin to tremble or shiver. This is a reaction caused as the brain is starved for glucose. The trembling is followed by a blank stare and the puppy lying on his side. He may also experience convulsions. After a time, the puppy will become comatose. His body will be limp, lifeless, and the tongue and gums will be a grayish/blue color. The body temperature will be subnormal. The puppy may even appear to be dead.
If caught in the early stages, treatment is simple. Rub Nutri-Cal (Caro syrup will do if you have no Nutri-Cal) on the puppy's gums, under the tongue, and on the roof of the mouth. (Caution: do not use honey.) Get a heating pad or heating blanket and slowly warm the puppy to proper body temperature. If the puppy responds, all is well. Feed a quality canned food right away (you may want to mix it with egg yolk) OR Gerber's baby food (chicken or beef) and then monitor the puppy to be sure that the condition does not recur. Be sure to eliminate the stress that caused the episode if at all possible.
If caught in the more advanced stages, treatment is more complicated. Always assume that the puppy is alive. Rub Nutri-Cal or Caro in the mouth, and carefully insert a small amount in the rectum. Slowly warm the puppy to normal body temperature (101-102 degrees F) and keep him warm continuously with light heat. If the puppy still does not respond, carefully eye dropper dextrose solution or Caro water into the mouth, a little at a time.
Call your veterinarian and inform him that you have a hypoglycemic puppy. He will prepare a warmed dextrose solution to inject subcutaneously and may put your puppy on an IV drip. Request a fecal exam.
Your puppy may have intestinal parasites such as worms, coccidia, or giardia that need to be eliminated immediately. A bacterial or viral infection may also be present and antibiotic treatment necessary. If your puppy has been given glucose injections, it is probably a good idea to treat him with antibiotics so that infection does not occur. Your vet will likely recommend a prescription canned food such as a/d to give as your puppy recovers. You can finger feed the a/d ‘as is' from the can and add Pedialyte to the drinking water. You must also keep the puppy warm at all times. Of course, use prudence, and do not overheat or dehydration will occur. In severe cases, you may need to force feed a/d for a time and give Pedialyte with a dropper. Give B vitamins to stimulate appetite. As your puppy improves he will begin to eat on his own and then you can gradually phase back in his regular food.
It is important to understand that just because a puppy has an episode of hypoglycemia, it does not mean that the puppy is truly "hypoglycemic." True hypoglycemia is a chronic condition caused by overproduction of insulin by the pancreas. Even though the pancreas may normally function properly, toy puppies can still have an isolated hypoglycemic incident in reaction to stress. Hypoglycemic incidents are almost always preceded by a stress of some kind.
Some examples of common stresses include weaning, teething, vaccinations, a change in environment, shipping, over-handling, cold temperatures, intestinal parasites, infections, anorexia, etc. Many puppies simply play too hard and stress their system or forget to eat. I have heard of young males experiencing hypoglycemia when a female in heat is around. They become so worked up over the female that they do not eat and their blood sugar drops.
Tiny dogs often do not have the fat reserves to supply adequate glucose in times of stress or when they do not eat regularly. Hypoglycemia most often occurs when the puppy has not eaten for several hours. This is not always the case, however. A puppy can have eaten recently and still show sings of hypoglycemia if his system is stressed and the food has not been digested and assimilated. It is important to "free feed" toy puppies a high-quality food. Toy puppies simply have too high of an energy level to be restricted to scheduled feedings. Most do fine if switched to scheduled feedings when they reach adulthood, but they must have access to food and water at all times when they are puppies. If you like to give your puppy canned food, you can schedule the feeding of the canned, but allow access to kibble at all times.
Always keep Nutri-Cal or Caro (Corn Syrup) on hand. This is the quickest way to revive a hypoglycemic puppy.

A summary of important reminders is as follows:
If you ever see your puppy becoming listless, or laying on his side and acting unresponsive IMMEDIATELY rub Nutri-Cal or Caro on his gums, under his tongue, and on the roof of the mouth. Slowly warm him to normal body temperature with a heating pad. Feed him as soon as he responds. Call your veterinarian if the puppy does not quickly respond.
Keep your puppy from chilling, free of parasites, and minimize stress.
See that your puppy eats often and maintains a proper body weight.
Do not over-handle your puppy. Be sure to allow him rest time and alone time. Like all babies, puppies need to have a regular schedule of rest, meals, play and potty.

Common Issues

Care For Your New Pup!

Changing Your Puppy's Food

Your puppy will be used to eating a certain food as their main diet, and abruptly changing their food can cause tummy problems. The best way to change your new puppy's diet is to slowly mix small amounts of food in with their usual food and gradually increase amounts until they are eating what you prefer to feed them. 

Bathing Your Puppy

Bathing your pup can be a great experience. Many dogs love water and the attention from their owners. We recommend not bathing your pup too often because this can result in irritation to their skin. While everyone loves cuddling with a clean puppy, causing dry skin can lead to other more serious problems. Your puppy's health is our main concern. 


Puppies need time to run around and release all of the energy that they build up while snoozing! The health benefits that your puppy gets from regular exercise are immense. There are many ways to exercise your new dog like walks, fetch, and giving them toys. There is an abundance of toys that can be bought to entertain your dog. Keeping them entertained is important because it gives them something to do so that they don't get into anything that could be destructive! Your pup would rather have fun with you then tear up your couch pillow. Dogs should be closely monitored with toys or any items in a room around them as things can be dangerous to a curious puppy. We recommend, that while your new puppy is exploring, to remove any cords or small items that are in the puppy's reach. Getting a new puppy is such a fabulous thing, but it is good to keep in mind that like a new born baby they will need a scheduled time to eat, as well as rest. At first, your don't want to handle your puppy for very long periods of time as they can become exhausted or hypoglycemic. These are rare cases that can be avoided with correct care for your puppy. Their life is extremely valuable. 

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